Evaluation and further development of the EASE model 2.0.

Examines the underlying structure and philosophy of the Estimation and Assessment of Substance Exposure (EASE) model version 2.0, developed by the UK Health and Safety Executive (HSE). EASE is a knowledge-based modal used by regulators for assessing new and existing substances. Aimed to provide a critical assessment of the utility of its performance to date. Information was documented by gathering surviving evidence and interviewing personnel involved in its creation and development. Twenty seven stakeholders participated in structured interviews on issues such as the limitations of the model, suggestions for improvement and accuracy and precision. They were also asked to comment on what outputs they would like to obtain from an ideal model. Outlines recommendations for the structure of a revised exposure model.